age-related macular degeneration in an iranian population

نویسندگان

حسن هاشمی

hassan hashemi الینا غفاری

elina ghafari مهدی خبازخوب

mehdi khabazkhoob ژیلا نوری

jila noori آرش طاهری

چکیده

purpose: to determine the prevalence and determinants of age-related macular degeneration (amd) in a 40-64 year old iranian populationmethods: in a cross-sectional study, 6,311 people were randomly selected from shahroud. for all participants, visual acuity, refraction, slit-lamp examination and fundus photography were conducted under pupil dilation. results: results of this study are based on analysis of 4,387 high quality photographs. the prevalence of amd in this study was 4.7% (95% confidence interval (ci): 4.1-5.4). multiple logistic regression analysis revealed that only older age [odds ratio (or)=1.07] and hyperopia (or=1.12) significantly correlated with amd. associations with biometric components and spherical equivalent were studied in another model and older age (or=1.08), male sex (or=1.54), and ocular axial length (or=0.66) significantly correlated with amd.  conclusion: amd prevalence in this population was lower compared to western countries and higher in comparison to east asian countries. in agreement with other studies, age strongly correlated with amd. regarding the correlation between amd and ocular axial length the incidence is more likely to occur in people with short axial lengths. iranian journal of ophthalmology 201426(4):203-11 © 2014 by the iranian society of ophthalmology

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Association of Apolipoprotein E Alleles with Susceptibility to Age-Related Macular Degeneration in Iranian Patients

Background: We aimed here to investigate the association between alleles and genotypes of APOE and Age-related macular degeneration (AMD) development. Materials and Methods: After ophthalmological examination, 120 patients with confirmed AMD and 120 healthy controls were enrolled in the study. The polymorphic segment of APOE gene was PCR-amplified and sequenced to determine the frequency distr...

متن کامل

بررسی اثر چندشکلی ژنتیکی xrcc7 با ریسک ابتلا به بیماریamd age-related macular degeneration))

amd بیماری تحلیل شبکیه است که عامل اصلی کوری در افراد بالای 55 سال در جهان غرب به شمار می-رود. در اثر این بیماری، لیپوپروتئین ها در شبکیه تجمع پیدا کرده و رگ زایی القاء می شود. ثابت شده است که عوامل ژنوتوکسیک محیطی مثل سیگار کشیدن، رژیم غذایی و نور در افراد پیر با زمینه ی ژنتیکی مستعد در بروز بیماری دخیل می باشند. بنابراین ما یک مطالعه ی مـورد- شاهـدی را ترتیب دادیم که شـامل 112 فرد مبتلا به am...

the genetics of age-related macular degeneration

age-related macular degeneration (amd) is the leading cause of blindness in old subjects. it is a multifactorial disease with both environmental and genetic factors playing some role in its pathogenesis. similar to many other genetic diseases, the inheritance pattern of amd does not fit into simple mendelian rules. these diseases are caused by the presence of multiple genetic factors and are ca...

متن کامل

Measurement of Choroidal Neovascular Area in Age-Related Macular Degeneration using Modified Otsu’s Thresholding Method

Introduction: Age-related Macular Degeneration (AMD) is one of the most important causes of irreversible  blindness in the developed world and  prevents the affected  person from  performing simple tasks such  as  reading,  driving  and  facial  recognition.  In  the  AMD,  new  blood  vessels  grow  underneath  the  retina  in  a  process  called  choroidal  neovascularisation  (CNV).  There  ...

متن کامل

age-related macular degeneration: a scientometric analysis

age-related macular degeneration (armd) is a major cause of central blindness among working aged adults across the world. systematic research planning on any subject, including armd is in need of solid data regarding previous efforts in this field and to identify the gaps in the research. this study aimed to elucidate the most important trends, directions, and gap in this subject. the data extr...

متن کامل

Prevalence of age-related macular degeneration in the US population.

OBJECTIVE To examine the prevalence of age-related macular degeneration (AMD) in non-Hispanic white, non-Hispanic black, Mexican American, and other racial/ethnic groups. DESIGN A US nationally representative, population-based, cross-sectional study involving a total of 5553 persons aged 40 years and older from the 2005-2008 National Health and Nutrition Examination Survey. The main outcome m...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
journal of current ophthalmology

جلد ۲۶، شماره ۴، صفحات ۲۰۳-۲۱۱

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023